Vasopressin suppresses mutual interaction between cytoplasmic tails of V1a receptors
نویسندگان
چکیده
منابع مشابه
Vasopressin receptors V1a and V2 are not osmosensors
Herein, we investigated whether G protein-coupled signaling via the vasopressin receptors of the V1a and V2 subtypes (V1aR and V2R) could be obtained as a direct response to hyperosmolar challenges and/or whether hyperosmolar challenges could augment classical vasopressin-dependent V1aR signaling. The V1aR-dependent response was monitored indirectly via its effects on aquaporin 4 (AQP4) when he...
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Starting from the 2.8-A resolution x-ray structure of bovine rhodopsin, three-dimensional molecular models of the complexes between arginine vasopressin and two receptor subtypes (V1a, V1b) have been built. Amino acid sequence alignment and docking studies suggest that four key residues (1.35, 2.65, 4.61, and 5.35) fine tune the binding of vasopressin and related peptide agonists to both recept...
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(1) Vasopressin (VP), or antidiuretic hormone, is secreted in response to either increases in plasma osmolality (very sensitive stimulus) or to decreases in plasma volume (less sensitive stimulus). Its normal plasma level is very low (about 1 pg/ml, i.e. 10(-12) M), close to the detection limit of present immunoassays, and distinct antidiuretic effects are observed after infusion of small undet...
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the TGN and ligand delivery to lysosomes. Deficiencies in both MPRs, or in addition of the mannose 6-phosphate tag, result in massive secretion of lysosome enzyme precursors into the extracellular milieu. In the yeast Saccharomyces cerevisiae, an analogous receptor-mediated pathway transports soluble hy-Los Angeles, California 90095 drolases to the lysosome-like vacuole, although sorting recept...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2019
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.92.0_2-yia-13